Recurrent chronic ambulatory peritoneal dialysisassociated infection due to rothia dentocariosa. Rothia dentocariosa endophthalmitis following intravitreal. Rothia dentocariosa previously known as stomatococcus mucilaginosus is a species of grampositive, round to rodshaped bacteria that is part of the normal community of microbes residing in the mouth and respiratory tract. Pdf abscess associated with rothia dentocariosa researchgate. Sep 14, 2015 view enhanced pdf access article on wiley online library html view download pdf for offline viewing. Rothia dentocariosa is a filamentous, facultatively anaerobic nonmotile, nonsporeforming, gram positive rod, which usually resides in the oral cavity.
Despite combined medical and surgical treatment, abscess formation progressed following aortic valve replacement, and the patient died during a second operative procedure. Rothia dentocariosa, a grampositive coccoid to rodshaped bacterium with irregular morphology, is a rare cause of bacteremia in patients. Rothia dentocariosa onishi 1949 georg and brown 1967, 68 al. The organism is slow growing and occasionally is isolated from.
An unknown, grampositive, ovoidshaped bacterium isolated from the nose of a mouse was subjected to a polyphasic taxonomic analysis. Rothia bacteremia journal of clinical microbiology asm. Rothia dentocariosa endophthalmitis following intravitreal injection. Table 1 demographic and clinical characteristics and clinical outcomes of patients with rothia bloodstream infections at mayo clinic, rochester, mn 20022012 variable dataa for. An elderly woman with rheumatoid arthritis and dental abscesses who was undergoing immunosuppression had r. Reboli, in mandell, douglas, and bennetts principles and practice of infectious diseases eighth edition, 2015. Infective endocarditis caused by rothia dentocariosa annals. Vitreous culture isolated rothia dentocariosa as the. Sensitivity of rothia dentocariosa journal of antimicrobial. Pdf rothia dentocariosa endocarditis with mitral valve. Polyphasic taxonomic evidence indicated that strain a117bt should be categorized together with the unofficially named rothia dentocariosa genomovar ii, but clearly differentiated them from the established species of the genus rothia. The first two species form part of the oropharyngeal microflora, and have been described as the causative agents of several diseases in humans. The pathogenicity of rothia dentocariosa, the prototype organism, was first demonstrated experimentally in.
Rothia dentocariosa septicemia without endocarditis in a. Rothia mucilaginosa pneumonia in an immunocompetent. Rothia mucilaginosa an overview sciencedirect topics. Tunkel, in mandell, douglas, and bennetts principles and practice of infectious diseases eighth edition, 2015. It occurs most frequently in patients with prior heart conditions. Rothia mucilaginosa was previously called as micrococcus mucilaginosa and stomatococcus mucilaginosa. By continuing to use our website, you are agreeing to our use of cookies. Identifying rothia dentocariosa annals of internal. Although the clinical course is typically subacute, it has a high rate of complications. Pdf recurrent chronic ambulatory peritoneal dialysis. Rothia dentocariosa is a nonmotile, nonsporeforming, nonacidfast, grampositive bacillus with variable morphology from coccoid to branching filamentous forms. R aeria however, has only once before been identified to cause endocarditis. Rothia mucilaginosa, previously known as stomatococcus muci laginosus, and other. Rothia mucilaginosa is a grampositive, coagulasenegative, encapsulated, nonsporeforming coccus considered part of the normal flora of the upper airway in humans.
Lower respiratory tract infections caused by this organism are rare and usually occur in immunocompromised patients. Rothia dentocariosa infectious disease and antimicrobial agents. In the past, it was known to be a cause for periodontal disease, but in recent years, rothia dentocariosa has been found to be the cause of several other infectious entities, of which endocarditis is the most predominant. Rothia aeria is a rothia species from the micrococcaceae family. The pathogenicity of rothia dentocariosa, the prototype organism, was first demonstrated experimentally in mice by roth and flanagan 2 in 1969. This is the case of an immunocompetent 47yearold woman with right upper lobe pneumonia in which r. In particular, the reported incidence of mycotic aneurysms is as high as 25%. Rothia dentocariosa, a pleomorphic grampositive branching bacillus, is a common inhabitant of the nose and throat. Rothia dentocariosa is a filamentous, facultatively. This report characterizes this rare organism and contributes to the literature on its pathogenicity and likely oral source. In summary, this is the first case report of infective endocarditis caused by r. Roth, who performed basic studies with these organisms. Native and prosthetic valve endocarditis caused by rothia. Rothia dentocariosa is a rare grampositive bacterial organism, one of the group of microbes that normally resides in the mouth and respiratory tract.
The first report of survival post rothia aeria endocarditis. Identifying rothia dentocariosa annals of internal medicine. Rothia dentocariosa is a common inhabitant of the cavities of the human mouth and throat 2, 3. Rothia mucilaginosa is a grampositive coccus that occurs as part of the normal flora of the oropharynx and upper respiratory tract. Peritonitis from rothia mucilaginosa in a chronic peritoneal. Comparative 16s rrna gene sequencing demonstrated that the unknown organism was a member of the family micrococcaceae and possessed a specific phylogenetic association with rothia dentocariosa and stomatococcus mucilaginosus. It is considered to have low virulence, but has been reported to cause infections in various organs in immunocompromised patients. Download fulltext pdf download fulltext pdf a case of bacteremia caused by rothia dentocariosa article pdf available january 2009 with 446 reads. Although it was first isolated from humans in 1949 1 and has subsequently been isolated from multiple sites 24, its potential as a human pathogen is unclear. Cells of this aerobic, creamyellowcoloured strain occurred singly, in pairs or in tetrads, were gramstainpositive and ovoid to sphericalshaped. P value all patients n 25neutropenic patients n 22nonneutropenic. Rothia bacteria can cause disease in humans and immunosuppressed humans.
Case of triple endocarditis caused by rothia dentocariosa and. This page was last edited on 3 february 2020, at 16. Rothia dentocariosa, a grampositive coccobacillus, is a commensal bacterium that is part of the oropharynx and respiratory tract. Rothia dentocariosa is a pleomorphic grampositive rod normally found in the human mouth that has been associated with dental cavities, periodontal disease1, and, rarely, as a cause of systemic infection2,3. Pdf rothia dentocariosa induces tnfalpha production in.
Rothia dentocariosa, a grampositive coccoid to rodshaped bacterium with irregular morphology, is a rare cause of bacteremia in patients without endocarditis. Pdf rothia dentocariosa, a pleomorphic, fastidious, grampositive. Pdf a case of bacteremia caused by rothia dentocariosa. The 15yearold had congenital aortic stenosis and insufficiency, and. Rothia mucilaginosa pneumonia diagnosed by quantitative. A 35yearold man with a history of intravenous drug use developed endocarditis due to rothia dentocariosa that was complicated by a perivalvular abscess. It is a wellknown causative agent of dental plaques and periodontal diseases. A novel endophytic actinobacterium, designated strain yim 67072t, was isolated from healthy roots of dysophylla stellata lour. The genus rothia has encountered many taxonomic changes in the last 15 years. Rothia mucilaginosa is a normal inhabitant of the human oral cavity and respiratory tract. The discrimination between nocardia spp and rothia aeria needs further analyses using malditofms andor 16s rrna.
The proportion of oral rothia species in saliva samples collected from 20 subjects was examined by culture method using orsm. The bacterium was first isolated from carious lesions. Rothia mucilaginosa is a grampositive coccus of the family micrococcaceae. Penicillin is the treatment of choice, but additional complications may necessitate prompt surgical. However, since 1975 there have been several reports of serious infections due to r.
Rothia are found as colonizers of the human oral cavity and have been isolated from dental plaque and in cases of periodontal disease. Rothia dentocariosa is a nonmotile, nonsporeforming, nonacidfast, grampositive bacillus with a variable morphology that includes coccoid and branching filamentous forms. This report addresses a possible mechanism of the little studied rothia dentocariosa rd to contribute to the inflammation associate with periodontal disease. Infective endocarditis caused by rothia dentocariosa. Notably, the authors demonstrate that two different strains of rd are able to elicit. Mitral endocarditis due to rothia aeria with cerebral. Rothia dentocariosa, an aerophilic grampositive coccobacillus, is part of the normal flora of the oral cavity. Rothia is a grampositive, aerobic, rodshaped and nonmotile bacterial genus from the family of micrococcaceae. As recent external quality control results have shown, the diagnosis of rothia dentocariosa infection still presents problems for clinical laboratories. The highest 16s rrna gene sequence similarities of strain l143t 98. Septic arthritis caused by rothia dentocariosa in a patient. Coccoid, spherical, dipththeroid, filamentous mycelial cells, usually up to 1.
Three cases, one each of native valve, prosthetic valve and composite graft endocarditis caused byrothia dentocariosa are described. The genus rothia was created by georg and brown 1 in 1967 to include members of the family actinomycetaceae that resemble nocardia and actinomyces morphologically but differ significantly in their physiology and cell wall constituents. The genus rothia belongs to the micrococcaceae family and at least four species have been recognized. Here, we describe 67 adults at the mayo clinic in rochester. The left eye was unaffected but had a bcva of 624 due to preexisting diabetic retinopathy. Documented cases occur chiefly in patients with valvular or dental disease, or both. We report the case of a previously healthy 58yearold man who presented with evidence of bacterial endocarditis caused by. Rothia aeria as a cause of sepsis in a native joint. A creamwhitecoloured, aerobic, grampositive, ovoid to sphericalshaped bacterial strain, designated l143t, was isolated from soil in taiwan.
Risk factors for rothia mucilaginosa previously known as stomatococcus mucilaginosus bacteremia include prolonged and profound neutropenia, malignancy, and an indwelling vascular foreign body. Rothia dentocariosa is a rare cause of endocarditis. Rothia aeria is an aerobic, grampositive, coccoidal and coccobacillary or filamentous bacterium that belongs to the micrococcaceae family see figure 1. Characterization of a rothialike organism from a mouse.
The glycolipid was found to be a dimannosylacylmonoglyceride in which the. Rothia aeria as a cause of sepsis in a native joint journal. Rothia dentocariosa endocarditis in an unsuspecting host. In addition, the records of two microbiology laboratories in france showed that r. Read rothia dentocariosa bacteremia, clinical microbiology newsletter on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Rothia dentocariosa an overview sciencedirect topics. As recent external quality control results have shown, the diagnosis of rothia dentocariosa infection still presents problems for. Rothia austin major reference works wiley online library. The first patient presented with multiple brain abscesses and severe congestive heart failure due to destructive endocarditis with large vegetations on the mitral valve. It is an infrequent pathogen, mostly affecting severely immunocompromised patients. Rothia dentocariosa endocarditis with mitral valve prolapse. Sensitivity of rothia dentocariosa, journal of antimicrobial chemotherapy, volum we use cookies to enhance your experience on our website.
This is the first case of endocarditis in which rothia dentocariosa was cultured from three affected valves. Actinobacteria actinobacteria micrococcales micrococcaceae rothia. Rothia aeria is a recently described grampositive rod from the family micrococcaceae. Two papers in this issue 1, 2 concern cases of bacterial endocarditis caused by rothia dentocariosa, an aerobic, nonmotile, nonsporeforming, pleomorphic, grampositive coccal to rodshaped bacterium see figure 1 often encountered by healthy medical students working with organisms from swabs of their throats as part of a laboratory exercise called the throat unknown. Dec 16, 2017 this report describes the first recognised case of rothia dentocariosa endophthalmitis following intravitreal injection. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. The most common rothia infection is endocarditis, typically. First isolated from dental caries, rothia dentocariosa is largely benign, but does very rarely cause disease. Isolation and identification methods of rothia species in. Infectious endocarditis caused by rothia dentocariosa was diagnosed in 2 patients, a 15yearold boy and a 57yearold woman. Rothia dentocariosa, endocarditis and mycotic aneurysms.
Rothia dentocariosa, mucilaginosa, nasimurium and amarae. Here, we describe 67 adults at the mayo clinic in rochester, mn, from. Files are available under licenses specified on their description page. Rothia mucilaginosa formerly stomatococcus mucilaginosus is a grampositive aerobic coccus that was traditionally found as a cause of oral, cutaneous, and central nervous system infections in impaired hosts.
Altogether, severity and antimicrobial susceptibility should make us consider the management of r. Morphological, physiological, chemotaxonomic and genomic characteristics supported the assignments of these strains to these genera, but they could not be classified as any existing species within each respective genus. Of the two cases of endocarditis secondary to rothia dentocar. Rothia dentocariosa induces tnfalpha production in a tlr2. Rothia dentocariosa, the type species of the genus, is an aerobic coccoid to rodshaped, nonsporogenic, nonmotile, catalasepositive grampositive bacterium.
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